Recently added works
2005-11-16
O-GlcNAcase catalyzes the removal of N-acetylglucosamine residues from serine and threonine residues of post-translationally modified proteins using a catalytic mechanism involving substrate-assisted…
2020-06-23
Author: Johal, Am, Author: Wong, Jackie
On this episode of Below the Radar, our host Am Johal and guest host Rachel Wong are joined by Jackie Wong. Jackie currently is the Director of Communications and Race Equity Project Director at Hua…
2007-12-08
Author: Stubbs, Keith A., Author: Scaffidi, Adrian, Author: Debowski, Aleksandra W., Author: Mark, Brian L., Author: Stick, Robert V., Author: Vocadlo, David J.
The NagZ class of retaining exo-glucosaminidases play a critical role in peptidoglycan recycling in Gram-negative bacteria and the induction of resistance to beta-lactams. Here we describe the…
2020-05-04
Author: Enkhbayar, Asura, Author: Haustein, Stefanie, Author: Barata, Germana, Author: Alperin, Juan Pablo
Despite its undisputed position as the biggest social media platform, Facebook has never entered the main stage of altmetrics research. In this study, we argue that the lack of attention by…
2020-06-03
BackgroundIncreasing numbers of older individuals opt to spend extended time abroad each year for lifestyle, health, and financial reasons. This practice is known as international retirement…
2013-08-15
Author: Deng, Lehua, Author: Tsybina, Polina, Author: Gregg, Katie J., Author: Mosi, Renee, Author: Zandberg, Wesley F., Author: Boraston, Alisdair B., Author: Vocadlo, David J.
Certain bacterial pathogens possess a repertoire of carbohydrate processing enzymes that process host N-linked glycans and many of these enzymes are required for full virulence of harmful human…
2006-12-23
Author: Whitworth, Garrett E., Author: Macauley, Matthew S., Author: Stubbs, Keith A., Author: Dennis, Rebecca J., Author: Taylor, Edward J., Author: Davies, Gideon J., Author: Greig, Ian R., Author: Vocadlo, David J.
O-GlcNAcase catalyzes the cleavage of β-O-linked 2-acetamido-2-deoxy-β-d-glucopyranoside (O-GlcNAc) from serine and threonine residues of post-translationally modified proteins. Two potent inhibitors…
2020-03-03
Author: Johal, Am, Author: Walker, John
On this episode of Below the Radar, our host Am Johal sits down with John Walker, an award-winning Canadian filmmaker widely known for his documentary films, such as Québec My Country Mon Pays (2016…
2020-06-09
Author: Tuyisenge, Germaine, Author: Hategeka, Celestin, Author: Luginaah, Isaac, Author: Cechetto, David F., Author: Rulisa, Stephen
BackgroundIn Rwanda, maternal community health workers (M-CHWs) are involved in the country’s overall health system. In maternal health, their role includes the provision of preventive and…
2020-06-18
Information literacy (IL) is fundamentally important for CS students and graduates who are required to write research papers and stay abreast of new technologies and ideas. However, IL is absent in…
2020-06-25
Author: Smith, Paige , Author: Abbott, Janice
On this episode of Below the Radar, we are joined by Janice Abbott, the CEO of Atira Women’s Resource Society. Our office’s Program Assistant Paige Smith sits down with Janice to discuss how the…
2020-06-30
On this episode of Below the Radar, our host Am Johal and guest host Fiorella Pinillos are joined by carla bergman, an independent scholar, filmmaker and producer. Alongside videomaker Corin Browne,…
2009-06-12
Author: Macauley, Matthew S., Author: Vocadlo, David J.
Increasing cellular O-GlcNAc levels through pharmacological inhibition of O-GlcNAcase, the enzyme responsible for removal of the O-GlcNAc post-translational modification, is being increasingly used…
2009-03-30
Author: Marcelo, Filipa, Author: He, Yuan, Author: Yuzwa, Scott A., Author: Nieto, Lidia, Author: Jiménez-Barbero, Jesús, Author: Sollogoub, Matthieu, Author: Vocadlo, David J., Author: Davies, Gideon D., Author: Blériot, Yves
Here we report the synthesis of a series of polyhydroxylated 3- and 5-acetamido azepanes and detail the molecular basis of their inhibition of family 84 glycoside hydrolases. These family 84 enzymes…
2009-08-28
Author: Greig, Ian R., Author: Macauley, Matthew S., Author: Williams, Ian H., Author: Vocadlo, David J.
Human O-GlcNAcase plays an important role in regulating the post-translational modification of serine and threonine residues with β-O-linked N-acetylglucosamine monosaccharide unit (O-GlcNAc). The…
2013-09-26
Author: Mondon, Martine, Author: Hur, Soo, Author: Vadlamani, Grishma, Author: Rodrigues, Prerana, Author: Tsybina, Polina, Author: Oliver, Antonio, Author: Mark, Brian L., Author: Vocadlo, David J., Author: Blériot, Yves
AmpC β-lactamase confers resistance to β-lactam antibiotics in many Gram negative bacteria. Inducible expression of AmpC requires an N-acetylglucosaminidase termed NagZ. Here we describe the…
2010-01-12
Author: He, Yuan, Author: Macauley, Matthew S., Author: Stubbs, Keith A., Author: Vocadlo, David J., Author: Davies, Gideon J.
N-Acetylglucosamine β-O-linked to serine and threonine residues of nucleocytoplasmic proteins (O-GlcNAc) has been linked to neurodegeneration, cellular stress response, and transcriptional regulation…
2020-06-25
Author: Punja, Zamir K., Author: Holmes, Janesse E.
Cannabis sativa L. (hemp, marijuana) produces male and female inflorescences on different plants (dioecious) and therefore the plants are obligatory out-crossers. In commercial production, marijuana…
2014-04-24
Author: Yuzwa, Scott A., Author: Vocadlo, David J.
Alzheimer disease (AD) is a growing problem for aging populations worldwide. Despite significant efforts, no therapeutics are available that stop or slow progression of AD, which has driven interest…
2020-05-08
Author: Wada, Mineko, Author: Sixsmith, Judith, Author: Harwood, Gail, Author: Cosco, Theodore D. , Author: Fang, Mei Lan, Author: Sixsmith, Andrew
BackgroundFunding bodies increasingly require researchers to write lay summaries to communicate projects’ real-world relevance to the public in an accessible way. However, research proposals and…