Resource type
Date created
2013-09-26
Authors/Contributors
Author: Mondon, Martine
Author: Hur, Soo
Author: Vadlamani, Grishma
Author: Rodrigues, Prerana
Author: Tsybina, Polina
Author: Oliver, Antonio
Author: Mark, Brian L.
Author: Vocadlo, David J.
Author: Blériot, Yves
Abstract
AmpC β-lactamase confers resistance to β-lactam antibiotics in many Gram negative bacteria. Inducible expression of AmpC requires an N-acetylglucosaminidase termed NagZ. Here we describe the synthesis and characterization of hydroxyazepane inhibitors of NagZ. We find that these inhibitors enhance the susceptibility of clinically relevant Pseudomonas aeruginosa to β-lactams.
Document
Identifier
DOI: 10.1039/C3CC46646A
Published as
Mondon, M., Hur, S., Vadlamani, G., Rodrigues, P., Tsybina, P., Oliver, A., Mark, B. L., Vocadlo, D. J., & Blériot, Y. (2013). Selective trihydroxyazepane NagZ inhibitors increase sensitivity of Pseudomonas aeruginosa to β-lactams. Chemical Communications, 49(93), 10983–10985. https://doi.org/10.1039/C3CC46646A
Publication details
Publication title
Chemical Communications
Document title
Selective Trihydroxyazepane NagZ Inhibitors Increase Sensitivity of Pseudomonas Aeruginosa to β-lactams
Date
2013
Volume
49
Issue
93
First page
10983
Last page
10985
Published article URL
Copyright statement
Copyright is held by the author(s).
Scholarly level
Peer reviewed?
Yes
Language
English
Member of collection
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