Selective Trihydroxyazepane NagZ Inhibitors Increase Sensitivity of Pseudomonas Aeruginosa to β-lactams

Resource type
Date created
2013-09-26
Authors/Contributors
Abstract
AmpC β-lactamase confers resistance to β-lactam antibiotics in many Gram negative bacteria. Inducible expression of AmpC requires an N-acetylglucosaminidase termed NagZ. Here we describe the synthesis and characterization of hydroxyazepane inhibitors of NagZ. We find that these inhibitors enhance the susceptibility of clinically relevant Pseudomonas aeruginosa to β-lactams.
Document
Identifier
DOI: 10.1039/C3CC46646A
Published as
Mondon, M., Hur, S., Vadlamani, G., Rodrigues, P., Tsybina, P., Oliver, A., Mark, B. L., Vocadlo, D. J., & Blériot, Y. (2013). Selective trihydroxyazepane NagZ inhibitors increase sensitivity of Pseudomonas aeruginosa to β-lactams. Chemical Communications, 49(93), 10983–10985. https://doi.org/10.1039/C3CC46646A
Publication title
Chemical Communications
Document title
Selective Trihydroxyazepane NagZ Inhibitors Increase Sensitivity of Pseudomonas Aeruginosa to β-lactams
Date
2013
Volume
49
Issue
93
First page
10983
Last page
10985
Copyright statement
Copyright is held by the author(s).
Scholarly level
Peer reviewed?
Yes
Language