Selective Trihydroxyazepane NagZ Inhibitors Increase Sensitivity of Pseudomonas Aeruginosa to β-lactams

Peer reviewed: 
Yes, item is peer reviewed.
Scholarly level: 
Faculty/Staff
Final version published as: 

Mondon, M., Hur, S., Vadlamani, G., Rodrigues, P., Tsybina, P., Oliver, A., Mark, B. L., Vocadlo, D. J., & Blériot, Y. (2013). Selective trihydroxyazepane NagZ inhibitors increase sensitivity of Pseudomonas aeruginosa to β-lactams. Chemical Communications, 49(93), 10983–10985. https://doi.org/10.1039/C3CC46646A

Date created: 
2013-09-26
Identifier: 
DOI: 10.1039/C3CC46646A
Abstract: 

AmpC β-lactamase confers resistance to β-lactam antibiotics in many Gram negative bacteria. Inducible expression of AmpC requires an N-acetylglucosaminidase termed NagZ. Here we describe the synthesis and characterization of hydroxyazepane inhibitors of NagZ. We find that these inhibitors enhance the susceptibility of clinically relevant Pseudomonas aeruginosa to β-lactams.

Language: 
English
Document type: 
Article
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Rights remain with the authors.
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