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Fluorescence angular domain imaging with stabilized intralipid test phantom

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Thesis type
(Thesis) M.A.Sc.
Date created
Optical imaging through biological tissue has the significant challenge of scattering which degrades the image resolution and quality. Angular Domain Imaging (ADI) improves image quality by filtering out the scattered light in the biological tissue images based on the angular direction of photons. Using a newly developed solid fluorescing scattering phantom (SR = 17000, µs’ = 48.4cm-1), this allows us to couple ADI with conventional fluorescence imaging technique. We created a new solid phantom which mimics human skin tissue with a patterned fluorescing collagen layer. These phantoms have stability over 6 months, much longer than traditional tissue phantoms. Monte Carlo simulations analyzed the angular filtration performance with the new low aspect ratio 2D-Collimating Arrays (2D-AFA) under shallow scattering depth fluorescing scenario. Applying the ADI filters, 2D-AFA and SpatioFrequency Filter (SFF), to the scattering sample, we detected resolution targets (200µm - 400µm) embedded inside the medium.
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Scholarly level
Supervisor or Senior Supervisor
Thesis advisor: Chapman, Glenn H.
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