Patient comprehension of HIV antiviral drug resistance: implications for treatment and clinical practice

A patient’s health literacy can affect their decisions regarding treatment. Patient knowledge of developing HIV drug resistance and their treatment outcomes were explored in a cohort of HIV+ persons on HAART. Data was obtained from the Longitudinal Investigation into Supportive and Ancillary health services (LISA) study and a linkage with the Drug Treatment Program (DTP) at the BC Centre for Excellence in HIV/AIDS. Less than 4% completely defined HIV resistance and 20% reported not discussing resistance with their physician. The model showed discussing medication with physicians and receiving counseling by a pharmacist are predictive of completely or partially defining HIV antiviral drug resistance. Understanding of HIV resistance showed no differences in clinical variables, however, overall adherence and complete understanding of HIV resistance is low. If patient knowledge were improved through discussions with physicians and pharmacists, the potential exists to enhance overall adherence and treatment outcomes in a self-management system.