Skip to main content

Effects of a histamine H3 receptor antagonist on the development of sexually dimorphic behaviours

Resource type
Thesis type
(Thesis) M.A.
Date created
2008
Authors/Contributors
Abstract
Histamine antagonists in developing rats delay puberty, disrupt sexual behaviour in males, and abolish sex differences in the open field test suggesting that this system may regulate sexual differentiation. The effects of histamine during the critical period for androgenic masculinization of the nervous system are currently unknown. Perinatal exposure to the H3 antagonist thioperamide on the development of sexually dimorphic behaviours in adult Sprague-Dawley rats was investigated. Pregnant dams (E14-E20) and their pups (PND1-PND7) were subcutaneously injected with thioperamide (5mg/kg) or saline and observed for changes in the elevated plus maze, open field test, sexual behaviour, and radial arm water maze. Thioperamide attenuated sex differences in the elevated plus maze and open field test but did not affect sexual performance or learning in the radial arm water maze. The present findings suggest evidence of long-term neurobehavioral consequences in anxiety and exploratory behaviours after developmental manipulation of the histaminergic system.
Document
Copyright statement
Copyright is held by the author.
Permissions
The author has not granted permission for the file to be printed nor for the text to be copied and pasted. If you would like a printable copy of this thesis, please contact summit-permissions@sfu.ca.
Scholarly level
Language
English
Member of collection
Download file Size
etd4083.pdf 29.27 MB

Views & downloads - as of June 2023

Views: 16
Downloads: 0