Development and validation of a scale to measure therapeutic misunderstanding with respect to clinical trial research participation

Resource type
Thesis type
(Thesis) M.A.
Date created
Clinical trial research participants often exhibit therapeutic misunderstanding. Factor and item analyses of responses by 464 community-dwelling older adults (age 49+) recruited online enabled the development of the 23-item Therapeutic Misunderstanding Scale (TMU). In accord with Horn and Grady’s three facets definition (2003), a three-factor structure was supported by both exploratory and confirmatory factor analyses (n = 164 & n = 300 respectively). Internal consistency of responses to the full TMU as well as the therapeutic misconception, misestimation, and optimism subscales was calculated as alpha = .90, alpha =.87, alpha =.79, and alpha =.75, respectively. Correlations between the TMU and related instruments by 37 clinical trial participants provide support for convergent and discriminant validity of responses to this scale. Test-retest reliability was found to be r = .54 over an average interval of 35 weeks. Results are discussed in context of ongoing challenges to define and measure therapeutic misunderstanding.
Copyright statement
Copyright is held by the author.
The author has not granted permission for the file to be printed nor for the text to be copied and pasted. If you would like a printable copy of this thesis, please contact
Scholarly level
Member of collection
Download file Size
etd2915.pdf 6.94 MB

Views & downloads - as of June 2023

Views: 0
Downloads: 0