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Development of an improved separation system for Hg-197 from proton-irradiated gold targets

Resource type
Thesis type
(Thesis) M.Sc.
Date created
2024-06-14
Authors/Contributors
Author (aut): Chen, Shaohuang
Abstract
Recent years have witnessed a boom in the development of radiopharmaceuticals, a novel cancer treatment. A key contributor to this endeavor is securing a stable supply of medical radionuclides. Mercury-197 has great potentials in radiopharmaceutical development thanks to its desirable decay properties. However, there exists a lack of separation strategies for this radionuclide. This work aims at addressing this problem. Mercury-197 is produced by irradiating natural gold with protons. Firstly, the standardization of a published column chromatography separation method with LN resin was performed. Later, the distribution coefficients of mercury and gold were measured on six resins to study their chemical behavior, aiming to find a superior method to using the LN resin. Furthermore, a second column filled with Weak Base Extraction Chromatographic (WBEC) resin was applied to both ready the 197Hg for subsequent radiolabeling and reduce the amount of co-existing impurities found in the purified 197Hg solution.
Document
Extent
122 pages.
Identifier
etd23124
Copyright statement
Copyright is held by the author(s).
Permissions
This thesis may be printed or downloaded for non-commercial research and scholarly purposes.
Supervisor or Senior Supervisor
Thesis advisor (ths): Ramogida, Caterina
Thesis advisor (ths): Radchenko, Valery
Language
English
Member of collection
Download file Size
etd23124.pdf 7.67 MB

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