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Supplementary data for the thesis The multi-omic characterization of pediatric and adult Burkitt lymphoma

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Authors/Contributors
Abstract
Supporting supplemental data tables for the associated thesis "The multi-omic characterization of pediatric and adult Burkitt lymphoma".
The file SupplementalTablesA.xlsx contains 14 supplementary tables necessary to support the main findings described in Chapter 2.
Table A1: Metadata and statistics of newly sequenced BL samples used in this study.
Table A2: MYC breakpoints identified in newly sequenced BL tumours constituting the study cohorts.
Table A3: Annotated coding simple somatic mutations across newly sequenced BL tumours.
Table A4: Genes deemed as significantly mutated across BL cohort.
Table A5: Comparison of mutations in single genes and gene groups between BLs stratified on EBV status.
Table A6: Comparison of mutations in single genes and gene groups between BLs stratified on age.
Table A7: Relative exposure of SBS signatures across newly sequenced BL samples used in this study.
Table A8: Identified copy-number variations in newly sequenced BL tumours constituting the study cohorts.
Table A9: Recurrent copy-number aberrations identified by GISTIC2.0 analysis.
Table A10: Tabulated binary matrix of genomic features used as input for NMF clustering.
Table A11: Subgroup assignment for BL tumours.
Table A12: IRF4 and TNFRSF13B expression in BL tumors measured by RNASeq and NanoString assays.
Table A13: Deferentially expressed genes between BL tumours in IC-BL and DGG-BL subgroups.
Table A14: Deferentially expressed pathways between BLs classified as IC-BL and DGG-BL.

The file Supplemental_tablesC.xlsx contains 12 supplementary tables necessary to support the main findings described in Chapter 3.
Table C1: Shared differentially methylated regions between EBV-positive BL and normal centroblasts.
Table C2: Shared differentially methylated regions between EBV-negative BL and normal centroblasts.
Table C3: Shared differentially methylated regions between EBV-positive and EBV-negative BL compared to normal centroblasts.
Table C4: Differentially methylated regions in BL based on EBV status.
Table C5: Significant correlations between differentially methylated regions based on EBV status and gene expression.
Table C6: Epitype assignment of samples.
Table C7: 60 probes identified by LPS defining the epitypes.
Table C8: Differentially methylated regions in BL based on epitype between HyperBL and HypoBL.
Table C9: Significant correlations between differentially methylated regions based on epitype and gene expression.
Table C10: JASPAR transcription factor binding site enrichment results based on epitype.
Table C11: JASPAR transcription factor binding site enrichment results based on EBV status.
Table C12: Differentially expressed genes based on epitype between HyperBL and HypoBL.
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etd22866
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Contact
nthomas@sfu.ca
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Research ethics approval has been obtained

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