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Examining the sequence and function of HIV Gag- specific T cell receptors restricted by HLA-B*57 and HLA-E

Resource type
Thesis type
(Thesis) M.Sc.
Date created
2023-12-04
Authors/Contributors
Abstract
Antiretroviral therapy suppresses HIV viremia, but no vaccine or cure exists. Rare individuals who spontaneously control infection mount robust antiviral CD8 T cell responses, indicating that these cells are crucial. T cell receptors (TCR) recognize viral peptides presented on infected cells by HLA. HLA are diverse, but only classical HLA-A,-B, and -C alleles were thought to contribute to the HIV response. Recent studies identified T cells that recognize HIV Gag KF11 (KAFSPEVIPMF) presented by non- classical HLA-E, providing a new mechanism for control. My thesis examined the sequence and function of KF11-specific TCR in the context of HLA-B*57 and HLA-E. I identified seven highly functional TCR, including one likely dual HLA-restricted clone. These TCR displayed substantial sequence similarity and all required KF11 position 6 (E) for recognition. My results highlight features of KF11-specific TCR that may support efforts to develop a more effective vaccine to prevent HIV infection.
Document
Extent
111 pages.
Identifier
etd22826
Copyright statement
Copyright is held by the author(s).
Permissions
This thesis may be printed or downloaded for non-commercial research and scholarly purposes.
Supervisor or Senior Supervisor
Thesis advisor: Brockman, Mark
Language
English
Download file Size
etd22826.pdf 3.8 MB

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