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The relationship between sleep and performance on tests of pattern separation and the Cambridge Neuropsychological Test Automated Battery (CANTAB)

Resource type
Thesis type
(Thesis) M.A.
Date created
2023-11-27
Authors/Contributors
Abstract
Sleep disturbances are considered both a risk factor for and symptom of Alzheimer's disease (AD). To identify sleep-dependent cognitive tests, we monitored rest and activity patterns for 7 days in younger (N=89, 18-30 years) and older (N=40, 50-100 years) adults. We then assessed the effects of 24-hour sleep deprivation in sleep-deprived (N=16, 18-40 years) and rested (N=32, 18-40 years) participants. Cognitive performance assessments included the Mnemonic Similarity Task (MST) and CANTAB. We observed a stronger, but not statistically significant relationship between sleep quantity and MST performance in the older adults compared to the younger adults, and statistically significant relationships between performance on the CANTAB DMS and sleep quality in the older adults. In Study 2, the sleep-deprived participants showed poorer MST performance and longer DMS response latencies than rested participants, but relationships were not statistically significant. Sleep-dependent cognitive tests could be used as clinical trial outcome measures for sleep-promoting treatments.
Document
Extent
128 pages.
Identifier
etd22848
Copyright statement
Copyright is held by the author(s).
Permissions
This thesis may be printed or downloaded for non-commercial research and scholarly purposes.
Supervisor or Senior Supervisor
Thesis advisor: Kent, Brianne
Language
English
Member of collection
Download file Size
etd22848.pdf 3.02 MB

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