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Chemical activity-based risk assessment of Perfluorooctane Sulfonate (PFOS)

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Thesis type
(Thesis) M.R.M.
Date created
Traditional methods for assessing the environmental risks associated with perfluorooctane sulfonate (PFOS) have faced challenges due to its ionic, poorly lipid-soluble, non-volatile, and surface-active nature. To support current environmental management practices for PFOS, this thesis applies the concept of chemical activity to facilitate the comparison of its exposure and toxicity concentrations. Through this approach, a wide range of concentration data from various media, units, and sources are integrated, enabling a more comprehensive evaluation of its environmental distribution and potential risks. To support the measurement of apparent chemical activity, a technique of solid-phase microextraction (SPME) through thin-films of ethylene vinyl acetate (EVA) is developed. This technique can also be used to determine samples' concentration, sorptive capacity, and partition coefficient of PFOS. Results show that the sorptive capacity of PFOS in aqueous solutions is influenced by factors such as ionic strength and potentially temperature, while the partition coefficients between EVA and solution (KEVA-Soln) and serum albumin and solution (KBSA-Soln) are dependent on the concentrations of PFOS and serum albumin. These observations are likely attributed to the surfactant nature of PFOS, which complicates its behaviour in solution and interaction with receptor media such as EVA and serum albumin. Given the complex physicochemical properties of PFOS that may be influenced by varying conditions, direct measurements through EVA SPME offer a practical tool for supporting a chemical activity-based environmental risk assessment of PFOS.
91 pages.
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Copyright is held by the author(s).
This thesis may be printed or downloaded for non-commercial research and scholarly purposes.
Supervisor or Senior Supervisor
Thesis advisor: Gobas, Frank
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