The design of high-speed and multi-scale in vivo retinal imaging with wavefront sensorless adaptive optics optical coherence tomography

Human retinal imaging is rapidly growing industry due to the special characteristics of the eye which has irreversible vision-robbing diseases. Optical Coherence Tomography (OCT) is routinely applied for retinal imaging since it provides three-dimensional retinal images non-invasively. With advancements of the technology, current commercial OCT systems in clinics are able to zoom in and out the region of interest, visualizing and acquiring various features of the retina image in several seconds. However, still there are limitations of achievable imaging angle, image quality and acquisition speed that need to be improved. In this thesis, we introduce the multi-scale feature, adjusting the beam diameter (and hence the resolution) to match each field-of-view to improve the image quality. Furthermore, this system employed a recently developed light source which provides much faster imaging speed which is critical to minimize motion artifacts, providing various potential to enhance the image quality.