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A pedigree-transmission likelihood for multiplex families

Resource type
Thesis type
(Project) M.Sc.
Date created
2023-04-06
Authors/Contributors
Author: Yang, Tianyu
Abstract
Family-based studies of a genetically inherited disease ascertain so-called multiplex pedigrees with several disease-affected members. A parameter of interest in these studies is the probability that a parent transmits a given genetic variant to their child. I describe a likelihood method for estimating the transmission probability of a rare genetic variant based on DNA sequencing data in affected relatives. These pedigree-transmission likelihoods are based on data for the presence or absence of the variant in the affected relatives. I describe how to implement the likelihoods using software for Bayesian Networks in R. The ideas are illustrated with several example pedigrees of various shapes and sizes.
Document
Extent
24 pages.
Identifier
etd22489
Copyright statement
Copyright is held by the author(s).
Permissions
This thesis may be printed or downloaded for non-commercial research and scholarly purposes.
Supervisor or Senior Supervisor
Thesis advisor: Graham, Jinko
Language
English
Download file Size
etd22489.pdf 318.59 KB

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