Efforts have been directed towards the total synthesis of eleutherobin, a natural product with promising anticancerous properties. Indeed, Taxol-like activity of eleutherobin could provide an interesting alternative to Taxol-resistant cancers. The generation of the 10-membered ring has been performed via an exotic Knoevenagel condensation and paves the path for a concise, robust and efficient synthesis of the marine natural product. An additional study describes the synthesis of several inhibitors for the production of afucosylated antibodies that will ultimately provide a considerable enhancement of their antibody-dependent cell-mediated cytotoxicity. Alone or combined with toxic payloads (i.e., ADC), these antibodies will contribute to better and cheaper immunotherapies for cancer.
Copyright is held by the author(s).
This thesis may be printed or downloaded for non-commercial research and scholarly purposes.
Supervisor or Senior Supervisor
Thesis advisor: Britton, Robert
Member of collection