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Studies towards the total synthesis of eleutherobin and biologically active carbasugars

Resource type
Thesis type
(Thesis) Ph.D.
Date created
2022-01-24
Authors/Contributors
Abstract
Efforts have been directed towards the total synthesis of eleutherobin, a natural product with promising anticancerous properties. Indeed, Taxol-like activity of eleutherobin could provide an interesting alternative to Taxol-resistant cancers. The generation of the 10-membered ring has been performed via an exotic Knoevenagel condensation and paves the path for a concise, robust and efficient synthesis of the marine natural product. An additional study describes the synthesis of several inhibitors for the production of afucosylated antibodies that will ultimately provide a considerable enhancement of their antibody-dependent cell-mediated cytotoxicity. Alone or combined with toxic payloads (i.e., ADC), these antibodies will contribute to better and cheaper immunotherapies for cancer.
Document
Extent
218 pages.
Identifier
etd21800
Copyright statement
Copyright is held by the author(s).
Permissions
This thesis may be printed or downloaded for non-commercial research and scholarly purposes.
Supervisor or Senior Supervisor
Thesis advisor: Britton, Robert
Language
English
Member of collection
Download file Size
etd21800.pdf 5.65 MB

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