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Ferrocene as a redox-active auxiliary for novel anticancer agents

Resource type
Thesis type
(Thesis) M.Sc.
Date created
2023-01-19
Authors/Contributors
Abstract
Two sets of novel ferrocene-conjugated compounds have been developed as novel anticancer agents. In the first case these are ferrocene (Fc) functionalized coumarin and anthraquinone. Electron paramagnetic resonance (EPR) spin-trapping studies show that the Fc group has an intrinsic ability to generate reactive oxygen species (ROS), with, in vitro studies confirming this also occurs in MCF-7 cancer cells. The Fc-coumarin compound showed promising cytotoxic activity. The second case of compounds revolve around Fc-conjugated derivatives of anticancer Ru(II)-arenes. DNA interaction studies displayed promising results for the Fc-Ru(II) heteronuclear bimetallic compounds. However, although in vitro cytotoxicity studies showed promising activity for the parent compounds, the Fc-conjugated complexes were less active. Cellular uptake studies using ICP-MS were performed to confirm Fc conjugation negatively impacted on internalization, likely due to increased lipophilicity.
Document
Extent
165 pages.
Identifier
etd22328
Copyright statement
Copyright is held by the author(s).
Permissions
This thesis may be printed or downloaded for non-commercial research and scholarly purposes.
Supervisor or Senior Supervisor
Thesis advisor: Walsby, Charles
Language
English
Member of collection
Download file Size
etd22328.pdf 5.66 MB

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