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Causal and Bayesian exploration of walking energy expenditure and oxygen kinetics in children with cerebral palsy

Resource type
Thesis type
(Thesis) M.Sc.
Date created
2022-12-16
Authors/Contributors
Abstract
The goal of this thesis is to understand why children with cerebral palsy (CP) expend more energy and fatigue faster when walking than their typically developing peers. I used a large observational database from children with CP in combination with causal and Bayesian statistics to accomplish this goal. For my first project, I estimated the causal effects of various biomechanical and neuromuscular factors on walking metabolic power. Metabolic power was most influenced by impaired kinematics and motor control. In my second project, I quantified the time rate of oxygen kinetics in children with CP. I found they had slower oxygen kinetics than what has been reported for children with typical development. This indicates they might also have greater metabolite flux from greater anaerobic energy production and could explain faster rates of fatigue. Together, these projects suggest that biomechanical and physiological differences underlie greater energy expenditure and fatigue in children with CP.
Document
Extent
83 pages.
Identifier
etd22310
Copyright statement
Copyright is held by the author(s).
Permissions
This thesis may be printed or downloaded for non-commercial research and scholarly purposes.
Supervisor or Senior Supervisor
Thesis advisor: Donelan, Max
Language
English
Download file Size
etd22310.pdf 31.21 MB

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