Impacts of medication use on child gut microbiota outcomes in the CHILD cohort study

Resource type
Thesis type
(Thesis) M.Sc.
Date created
2022-07-12
Authors/Contributors
Abstract
The gut microbiota is a complex ecosystem playing a role in health, primarily colonized in the first year of life. Some medication use, such as antibiotics, can cause microbial dysbiosis (unusual microbiome composition) and is associated with development of pathologies such as asthma. However, the impact of other medication use on the gut microbiome is poorly characterized. In this thesis, I use the rich data collected in the CHILD Cohort Study, to develop models examining the impacts of medication practices on infant microbial dysbiosis and associated child outcomes. Certain medication use was associated with changes in the gut microbiome, but the results suggest medication use may be a proxy for other lifestyle factors that make the child more prone to microbial dysbiosis. This work forms the base for further characterizations of the links between medication use, metabolism, and lifestyle, to identify the most effective intervention points for preventing microbial dysbiosis.
Document
Extent
181 pages.
Identifier
etd21997
Copyright statement
Copyright is held by the author(s).
Permissions
This thesis may be printed or downloaded for non-commercial research and scholarly purposes.
Supervisor or Senior Supervisor
Thesis advisor: Brinkman, Fiona
Language
English
Attachment Size
etd21997.pdf 6.48 MB