Mouse Organ-Specific Proteins and Functions

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Sun, B., Lorang, C., Qin, S., Zhang, Y., Liu, K., Li, G., Sun, Z., Francke, A., Utleg, A. G., Hu, Z., Wang, K., Moritz, R. L., & Hood, L. (2021). Mouse Organ-Specific Proteins and Functions. Cells, 10(12).

Date created: 
DOI: 10.3390/cells101234494
Mouse proteome
Organ proteome
Proteome dynamics
Proteome diversity
Organspecific proteins
Brain proteome
Liver proteome
Kidney proteome
Pancreas proteome
Spleen proteome
Heart proteome
Skeletal muscle proteome
Intestine proteome
Bone proteome
Eye proteome
Testis proteome
Lung proteome
Fat proteome

Organ-specific proteins (OSPs) possess great medical potential both in clinics and in biomedical research. Applications of them—such as alanine transaminase, aspartate transaminase, and troponins—in clinics have raised certain concerns of their organ specificity. The dynamics and diversity of protein expression in heterogeneous human populations are well known, yet their effects on OSPs are less addressed. Here, we used mice as a model and implemented a breadth study to examine the panorgan proteome for potential variations in organ specificity in different genetic backgrounds. Using reasonable resources, we generated panorgan proteomes of four in-bred mouse strains. The results revealed a large diversity that was more profound among OSPs than among proteomes overall. We defined a robustness score to quantify such variation and derived three sets of OSPs with different stringencies. In the meantime, we found that the enriched biological functions of OSPs are also organ-specific and are sensitive and useful to assess the quality of OSPs. We hope our breadth study can open doors to explore the molecular diversity and dynamics of organ specificity at the protein level. 

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