Skeletal Muscle Pump Drives Control of Cardiovascular and Postural Systems

Resource type
Date created
2017-03-27
Authors/Contributors
Abstract
The causal interaction between cardio-postural-musculoskeletal systems is critical in maintaining postural stability under orthostatic challenge. The absence or reduction of such interactions could lead to fainting and falls often experienced by elderly individuals. The causal relationship between systolic blood pressure (SBP), calf electromyography (EMG), and resultant center of pressure (COPr) can quantify the behavior of cardio-postural control loop. Convergent cross mapping (CCM) is a non-linear approach to establish causality, thus, expected to decipher nonlinear causal cardio-postural-musculoskeletal interactions. Data were acquired simultaneously from young participants (25 ± 2 years, n = 18) during a 10-minute sit-to-stand test. In the young population, skeletal muscle pump was found to drive blood pressure control (EMG → SBP) as well as control the postural sway (EMG → COPr) through the significantly higher causal drive in the direction towards SBP and COPr. Furthermore, the effect of aging on muscle pump activation associated with blood pressure regulation was explored. Simultaneous EMG and SBP were acquired from elderly group (69 ± 4 years, n = 14). A significant (p = 0.002) decline in EMG → SBP causality was observed in the elderly group, compared to the young group. The results highlight the potential of causality to detect alteration in blood pressure regulation with age, thus, a potential clinical utility towards detection of fall proneness.
Document
Identifier
DOI: 10.1038/srep45301
Published as
Verma, A. K., Garg, A., Xu, D., Bruner, M., Fazel-Rezai, R., Blaber, A. P., & Tavakolian, K. (2017). Skeletal Muscle Pump Drives Control of Cardiovascular and Postural Systems. Scientific Reports, 7(1), 45301. https://doi.org/10.1038/srep45301.
Publication title
Scientific Reports
Document title
Skeletal Muscle Pump Drives Control of Cardiovascular and Postural Systems
Date
2017
Volume
7
Issue
1
Publisher DOI
10.1038/srep45301
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Copyright is held by the author(s).
Scholarly level
Peer reviewed?
Yes
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srep45301.pdf 507.51 KB