Resource type
Date created
2017-05-26
Authors/Contributors
Author: Alvarez‐Dorta, Dimitri
Author: King, Dustin T.
Author: Legigan, Thibaut
Author: Ide, Daisuke
Author: Adachi, Isao
Author: Deniaud, David
Author: Désiré, Jérôme
Author: Kato, Atsushi
Author: Vocadlo, David
Author: Gouin, Sébastien G.
Author: Blériot, Yves
Abstract
A set of multivalent polyhydroxylated acetamidoazepanes based on ethylene glycol, glucoside, or cyclodextrin scaffolds was prepared. The compounds were assessed against plant, mammalian, and therapeutically relevant hexosaminidases. Multimerization was shown to improve the inhibitory potency with synergy, and to fine tune the selectivity profile between related hexosaminidases.
Document
Identifier
DOI: 10.1002/chem.201701756
Published as
Alvarez-Dorta, D., King, D. T., Legigan, T., Ide, D., Adachi, I., Deniaud, D., Désiré, J., Kato, A., Vocadlo, D., Gouin, S. G., & Blériot, Y. (2017). Multivalency To Inhibit and Discriminate Hexosaminidases. Chemistry – A European Journal, 23(38), 9022–9025. https://doi.org/10.1002/chem.201701756
Publication details
Publication title
Chemistry – A European Journal
Document title
Multivalency To Inhibit and Discriminate Hexosaminidases
Date
2017
Volume
23
Issue
38
First page
9022
Last page
9025
Published article URL
Copyright statement
Copyright is held by the author(s).
Scholarly level
Peer reviewed?
Yes
Language
English
Member of collection
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