A Selective Inhibitor Gal‐PUGNAc of Human Lysosomal β‐Hexosaminidases Modulates Levels of the Ganglioside GM2 in Neuroblastoma Cells

Resource type
Date created
2009-01-28
Authors/Contributors
Abstract
Gal‐PUGNAc (see picture), a highly selective inhibitor for β‐hexosaminidases HEXA and HEXB is cell‐permeable and modulates the activity of HEXA and HEXB in tissue culture, increasing ganglioside GM2 levels. Gal‐PUGNAc should allow the role of these enzymes to be studied at the cellular level without generating a complex chemical phenotype from concomitant inhibition of O‐GlcNAcase.
Document
Identifier
DOI: 10.1002/anie.200804583
Published as
Stubbs, K. A., Macauley, M. S., & Vocadlo, D. J. (2009). A Selective Inhibitor Gal-PUGNAc of Human Lysosomal β-Hexosaminidases Modulates Levels of the Ganglioside GM2 in Neuroblastoma Cells. Angewandte Chemie International Edition, 48(7), 1300–1303. https://doi.org/10.1002/anie.200804583.
Publication title
Angewandte Chemie International Edition
Document title
A Selective Inhibitor Gal‐PUGNAc of Human Lysosomal β‐Hexosaminidases Modulates Levels of the Ganglioside GM2 in Neuroblastoma Cells
Date
2009
Volume
48
Issue
7
First page
1300
Last page
1303
Copyright statement
Copyright is held by the author(s).
Scholarly level
Peer reviewed?
Yes
Language