Voltage-gated sodium channels (VGSC) increase invasiveness and metastatic potential in prostate cancer and may be a novel drug target for castration resistant prostate cancer. VGSC isoforms expressed in prostate cancer differ depending on cell type, and laboratory growing conditions Immunocytochemistry experiments suggest that VGSC localize in invadopodia, structures required for invasiveness of cancer cells. VGSC significantly colocalize with vimentin, a marker of invadopodia (p
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Thesis advisor: Ruben, Peter
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