Voltage-gated sodium channels and their role in prostate cancer

Resource type
Thesis type
(Thesis) M.Sc.
Date created
2019-12-09
Authors/Contributors
Abstract
Voltage-gated sodium channels (VGSC) increase invasiveness and metastatic potential in prostate cancer and may be a novel drug target for castration resistant prostate cancer. VGSC isoforms expressed in prostate cancer differ depending on cell type, and laboratory growing conditions Immunocytochemistry experiments suggest that VGSC localize in invadopodia, structures required for invasiveness of cancer cells. VGSC significantly colocalize with vimentin, a marker of invadopodia (p
Document
Identifier
etd20692
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Copyright is held by the author.
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This thesis may be printed or downloaded for non-commercial research and scholarly purposes.
Scholarly level
Supervisor or Senior Supervisor
Thesis advisor: Ruben, Peter
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