Midday Meals Do Not Impair Mouse Memory

Resource type
Date created
2018-11-19
Authors/Contributors
Abstract
Nocturnal mice fed in the middle of the light period exhibit food anticipatory rhythms of behavior and physiology under control of food-entrainable circadian clocks in the brain and body. This is presumed to be adaptive by aligning behavior and physiology with predictable mealtimes. This assumption is challenged by a report that daytime feeding schedules impair cognitive processes important for survival, including object memory and contextual fear conditioning assessed at two times of day. To further evaluate these effects, mice were restricted to a 6 h daily meal in the middle of the light or dark period and object memory was tested at four times of day. Object memory was not impaired by daytime feeding, and did not exhibit circadian variation in either group. To determine whether impairment might depend on methodology, experimental procedures used previously to detect impairment were followed. Daytime feeding induced food anticipatory rhythms and shifted hippocampal clock genes, but again did not impair object memory. Spontaneous alternation and contextual fear conditioning were also not impaired. Hippocampal memory function appears more robust to time of day and daytime feeding schedules than previously reported; day-fed mice can remember what they have seen, where they have been, and where it is dangerous.
Document
Published as
Power, S.C., Michalik, M.J., Couture-Nowak, S. et al. Midday meals do not impair mouse memory. Sci Rep 8, 17013 (2018). DOI: 10.1038/s41598-018-35427-y.
Publication title
Sci Rep
Document title
Midday Meals Do Not Impair Mouse Memory
Date
2018
Volume
8
Issue
17013
Publisher DOI
10.1038/s41598-018-35427-y
Copyright statement
Copyright is held by the author(s).
Scholarly level
Peer reviewed?
Yes
Language
Member of collection
Attachment Size
s41598-018-35427-y.pdf 1.69 MB