Synthesis of conformationally constrained inhibitors for glycoside hydrolases

Glycoside hydrolase (GH) enzymes are clinically relevant biological targets for drug development. Disfunction of the two lysosomal GHs β-glucocerebrosidase and α-galactosidase can lead to Gaucher and Fabry’s disease, respectively. With knowledge of their mechanisms of action it is possible to create compounds that would effectively modulate their activity and potentially restore the activity of dysfunctional enzymes. Therefore, this work considers the approach to the synthesis of such compounds and determination of their mode of action. In the future, these compounds can be used for the development of drug candidates.