Visible light wavefront sensorless adaptive optics optical coherence tomography

Optical Coherence Tomography (OCT) imaging has predominantly been performed using wavelengths in the near-infrared, however visible light (Vis) has been recently demonstrated, showing encouraging results for high quality retinal imaging. Using a broadband supercontinuum visible light source, a sensorless adaptive optics (SAO) multi-modal imaging system is presented driven by Vis-OCT for volumetric structural imaging, followed by acquisition of fluorescence emission from the sample. The coherence-gated, depth resolved Vis-OCT images can be used for image-guided SAO aberration correction when the fluorescent signal is too weak, providing structural and functional images with high resolution.