This project focuses on developing a tool which can perform registration between subcortical surfaces. Current MATLAB-based ‘Spherical Demons’ algorithm, although very useful for most cases, fails to successfully complete surface registration in some cases. Therefore, FreeSurfer has been incorporated with ‘spherical demons’ algorithm to improve the existing surface registration algorithm by utilizing FreeSurfer’s superior spherical parameterization algorithm to parameterize the surface. This significantly improved the quality (smoothness and uniformity) of the parameterization over the existing spherical mapping which led to successful surface registration between subcortical surfaces.
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