Skip to main content

Drosophila adducin interacts with synaptic modelling proteins: Draper and Discs-large

Resource type
Thesis type
(Thesis) M.Sc.
Date created
Manipulation of the postsynaptic hu-li tai-shao (hts) transcript can affect synaptic development and plasticity. Hts is an actin-spectrin binding protein that is situated close to the synaptic cell membrane where it can co-localize with many synaptic modelling proteins. Two proteins, Draper (Drpr) and Discs large (Dlg), were found to be regulated by Hts at the postsynaptic membrane of Drosophila 3rd instar larval NMJ. Interestingly, both interacting partners are known to be involved in synaptic remodeling, where Drpr is involved in synaptic pruning and Dlg is involved in the regulation of synaptic cell-cell adhesion. In this study I focused on the characterization of interactions between Hts and Drpr while looking into the possibility that Dlg serves as a mediator between these interactions. I found genetic interaction between hts and drpr, and saw a potential triple-protein-complex between Hts, Dlg and Drpr, which may work together to manipulate synaptic development.
Copyright statement
Copyright is held by the author.
The author granted permission for the file to be printed, but not for the text to be copied and pasted.
Scholarly level
Supervisor or Senior Supervisor
Thesis advisor: Krieger, Charles
Thesis advisor: Harden, Nicholas
Download file Size
etd8904_CZheng.pdf 3.87 MB

Views & downloads - as of June 2023

Views: 0
Downloads: 0