Population Attributable Fraction of type 2 Diabetes due to Physical Inactivity in Adults: A Systematic Review

BackgroundPhysical inactivity is a global pandemic. The population attributable fraction (PAF) of type 2 diabetes mellitus (T2DM) associated with physical inactivity ranges from 3% to 40%. The purpose of this systematic review was to determine the best estimate of PAF for T2DM attributable to physical inactivity and absence of sport participation or exercise for men and women.MethodsWe conducted a systematic review that included a comprehensive search of MEDLINE, EMBASE, SportDiscus, and CINAHL (1946 to April 30 2013) limited by the terms adults and English. Two reviewers screened studies, extracted PAF related data and assessed the quality of the selected studies. We reconstructed 95% CIs for studies missing these data using a substitution method.ResultsOf the eight studies reporting PAF in T2DM, two studies included prospective cohort studies (3 total) and six were reviews. There were distinct variations in quality of defining and measuring physical inactivity, T2DM and adjusting for confounders. In the US, PAFs for absence of playing sport ranged from 13% (95% CI: 3, 22) in men and 29% (95% CI: 17, 41) in women. In Finland, PAFs for absence of exercise ranged from 3% (95% CI: -11, 16) in men to 7% (95% CI: -9, 20) in women.ConclusionsThe PAF of physical inactivity due to T2DM is substantial. Physical inactivity is a modifiable risk factor for T2DM. The contribution of physical inactivity to T2DM differs by sex; PAF also differs if physical inactivity is defined as the absence of ‘sport’ or absence of ‘exercise’.Background:Physical inactivity is a global pandemic. The population attributable fraction (PAF) of type 2 diabetesmellitus (T2DM) associated with physical inactivity ranges from 3% to 40%. The purpose of this systematic reviewwas to determine the best estimate of PAF for T2DM attributable to physical inactivity and absence of sportparticipation or exercise for men and women.Methods:We conducted a systematic review that included a comprehensive search of MEDLINE, EMBASE,SportDiscus, and CINAHL (1946 to April 30 2013) limited by the terms adults and English. Two reviewers screenedstudies, extracted PAF related data and assessed the quality of the selected studies. We reconstructed 95% CIs forstudies missing these data using a substitution method.Results:Of the eight studies reporting PAF in T2DM, two studies included prospective cohort studies (3 total) andsix were reviews. There were distinct variations in quality of defining and measuring physical inactivity, T2DM andadjusting for confounders. In the US, PAFs for absence of playing sport ranged from 13% (95% CI: 3, 22) in men and29% (95% CI: 17, 41) in women. In Finland, PAFs for absence of exercise ranged from 3% (95% CI: -11, 16) in men to7% (95% CI: -9, 20) in women.Conclusions:The PAF of physical inactivity due to T2DM is substantial. Physical inactivity is a modifiable risk factorfor T2DM. The contribution of physical inactivity to T2DM differs by sex; PAF also differs if physical inactivity isdefined as the absence of‘sport’or absence of‘exercise’.