Personalized Risk Assessment of Drug-Related Harm Is Associated with Health Outcomes

Resource type
Date created
2013
Abstract
BackgroundThe Independent Scientific Committee on Drugs (ISCD) assigned quantitative scores for harm to 20 drugs. We hypothesized that a personalized, ISCD-based Composite Harm Score (CHS) would be associated with poor health outcomes in polysubstance users.MethodsA prospective community sample (n=293) of adults living in marginal housing was assessed for substance use. The CHS was calculated based on the ISCD index, and the personal substance use characteristics over four weeks. Regression models estimated the association between CHS and physical, psychological, and social health outcomes.ResultsPolysubstance use was pervasive (95.8%), as was multimorbid illness (median 3, possible range 0–12). The median CHS was 2845 (interquartile range 1865–3977). Adjusting for age and sex, every 1000-unit CHS increase was associated with greater mortality (odds ratio [OR] 1.47, 95% confidence interval [CI] 1.07–2.01, p = 0.02), and persistent hepatitis C infection (OR 1.29, 95% CI 1.02–1.67, p = 0.04). The likelihood of substance-induced psychosis increased 1.39-fold (95% CI 1.13–1.67, p = 0.001). The amount spent on drugs increased 1.51-fold (1.40–1.62, p < 0.001) and the odds of having committed a crime increased 1.74-fold (1.46–2.10, p < 0.001). Multimorbid illness increased 1.43-fold (95% CI 1.26–1.63, p < 0.001).ConclusionsGreater CHS predicts poorer physical, psychological, and social health, and may be a useful quantitative, personalized measure of risk for drug-related harm.
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Published as
Jones AA, Vila-Rodriguez F, Panenka WJ, Leonova O, Strehlau V, et al. (2013) Personalized Risk Assessment of Drug-Related Harm Is Associated with Health Outcomes. PLoS ONE 8(11): e79754. doi:10.1371/journal.pone.0079754
Publication title
PLoS ONE
Document title
Personalized Risk Assessment of Drug-Related Harm Is Associated with Health Outcomes
Date
2013
Volume
8
Issue
11
Publisher DOI
10.1371/journal.pone.007975
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Copyright is held by the author(s).
Scholarly level
Peer reviewed?
Yes
Language
Member of collection
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harm.pdf 2.7 MB

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