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Bone Marrow-Derived Cell Accumulation in the Brain in a Murine Model of Alzheimer’s Disease

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Thesis type
(Thesis) M.Sc.
Date created
One difficulty in treating some neurological disorders is that many pharmaceuticals cannot cross the blood brain barrier to reach affected areas. Human and animal studies have shown that bone marrow transplantation can result in the engraftment of donor-derived cells in the central nervous system (CNS) under certain conditions. Understanding these conditions will allow us to optimize recruitment of bone marrow-derived cells (BMDCs) to the CNS and, in the future, use these cells as vehicles for gene delivery. Using a triple transgenic mouse model of Alzheimer’s Disease (AD), I studied accumulation of amyloid-β, a pathological characteristic of AD, and association of BMDCs with amyloid-β. There were difficulties in maintaining chimerism after bone marrow transplantation in these mice. Reconstitution was achieved by depleting natural killer cell activity in the host, suggesting that hybrid resistance may be present.
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Supervisor or Senior Supervisor
Thesis advisor: Krieger, Charles
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