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Software based bioassay quantization using standard optical disc drives

Resource type
Thesis type
(Thesis) M.A.Sc.
Date created
This thesis describes the application of the compact disc technology as a rapid, low-cost, high capacity-screening platform for bioassays. Although the compact disc has been used by modifying the hardware of the detection mechanism (CD-drive) to achieve a ubiquitous and low-cost detection of biomolecules, minimal or no modification is ideal. This thesis investigates the possibility of an inexpensive, software based bioassay detection on CDs with, standard computer drives. Using a CD data analysis software called IsoBuster, biotin-streptavidin binding assays prepared on compact discs are read detected and quantized using error based detection mechanism with a high spatial accuracy. The research shows a sensitivity of detection of 270 μg/mL of streptavidin in solution with biotin-modified disc
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Scholarly level
Supervisor or Senior Supervisor
Thesis advisor: Parameswaran, Ash
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etd6229_MPallapa.pdf 3.97 MB

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