A Prospective Cohort Study of Biomarkers of Prenatal Tobacco Smoke Exposure: The Correlation between Serum and Meconium and Their Association with Infant Birth Weight

Resource type
Date created
2010
Authors/Contributors
Abstract
Background:The evaluation of infant meconium as a cumulative matrix of prenatal toxicant exposure requirescomparison to established biomarkers of prenatal exposure.Methods:We calculated the frequency of detection and concentration of tobacco smoke metabolites measured inmeconium (nicotine, cotinine, and trans-3′-hydroxycotinine concentrations) and three serial serum cotinineconcentrations taken during the latter two-thirds of pregnancy among 337 mother-infant dyads. We estimated theduration and intensity of prenatal tobacco smoke exposure using serial serum cotinine concentrations andcalculated geometric mean meconium tobacco smoke metabolite concentrations according to prenatal exposure.We also compared the estimated associations between these prenatal biomarkers and infant birth weight usinglinear regression.Results:We detected nicotine (80%), cotinine (69%), and trans-3′-hydroxycotinine (57%) in most meconiumsamples. Meconium tobacco smoke metabolite concentrations were positively associated with serum cotinineconcentrations and increased with the number of serum cotinine measurements consistent with secondhand oractive tobacco smoke exposure. Like serum cotinine, meconium tobacco smoke metabolites were inverselyassociated with birth weight.Conclusions:Meconium is a useful biological matrix for measuring prenatal tobacco smoke exposure and couldbe used in epidemiological studies that enroll women and infants at birth. Meconium holds promise as abiological matrix for measuring the intensity and duration of environmental toxicant exposure and future studiesshould validate the utility of meconium using other environmental toxicants.
Document
Published as
Background: The evaluation of infant meconium as a cumulative matrix of prenatal toxicant exposure requires
comparison to established biomarkers of prenatal exposure.
Methods: We calculated the frequency of detection and concentration of tobacco smoke metabolites measured in
meconium (nicotine, cotinine, and trans-3′-hydroxycotinine concentrations) and three serial serum cotinine
concentrations taken during the latter two-thirds of pregnancy among 337 mother-infant dyads. We estimated the
duration and intensity of prenatal tobacco smoke exposure using serial serum cotinine concentrations and
calculated geometric mean meconium tobacco smoke metabolite concentrations according to prenatal exposure.
We also compared the estimated associations between these prenatal biomarkers and infant birth weight using
linear regression.
Results: We detected nicotine (80%), cotinine (69%), and trans-3′-hydroxycotinine (57%) in most meconium
samples. Meconium tobacco smoke metabolite concentrations were positively associated with serum cotinine
concentrations and increased with the number of serum cotinine measurements consistent with secondhand or
active tobacco smoke exposure. Like serum cotinine, meconium tobacco smoke metabolites were inversely
associated with birth weight.
Conclusions: Meconium is a useful biological matrix for measuring prenatal tobacco smoke exposure and could
be used in epidemiological studies that enroll women and infants at birth. Meconium holds promise as a
biological matrix for measuring the intensity and duration of environmental toxicant exposure and future studies
should validate the utility of meconium using other environmental toxicants.
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Copyright is held by the author(s).
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Peer reviewed?
Yes
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