Utilizing the photothermal effect for releasing molecules from the surfaces of gold nanoparticles

File(s): 
Date created: 
2010
Supervisor(s): 
B
Department: 
Department of Chemistry - Simon Fraser University
Keywords: 
Gold nanoparticles, photothermal release, thermal release mechanism, retro-Diels-Alder reaction.
Abstract: 

Nanomaterials, with unique physical and chemical properties, have the potential to help in the development of drug delivery systems. Some of these properties can be attributed to the nanoscale dimension of these materials. By masking, targeting, and release of a therapeutic agent, these nanomaterials can provide a delivery system that would reduce side effects. Gold nanoparticles have been studied as a candidate for the drug delivery system. These materials can be decorated with molecules that have a thermally responsive reaction (i.e., Diels-Alder). In addition, gold nanoparticles when irradiated with a right wavelength of light produce heat. Consequently, the generated heat from nanoparticles causes a retro-Diels-Alder reaction, which release a segment of molecule (i.e., payload) from gold surfaces. This controlled release mechanism is a novel method to take advantage of the properties inherent in gold nanoparticles and have the potential to be used in drug delivery system.

Thesis type: 
Thesis (M.Sc.)
Description: 
The author has placed restrictions on the PDF copy of this thesis. The PDF is not printable nor copyable. If you would like the SFU Library to attempt to contact the author to get permission to print a copy, please email your request to summit-permissions@sfu.ca.
Language: 
English
Document type: 
Thesis
Rights: 
Copyright remains with the author
Statistics: