Multivalency To Inhibit and Discriminate Hexosaminidases

Peer reviewed: 
Yes, item is peer reviewed.
Scholarly level: 
Faculty/Staff
Final version published as: 

Alvarez-Dorta, D., King, D. T., Legigan, T., Ide, D., Adachi, I., Deniaud, D., Désiré, J., Kato, A., Vocadlo, D., Gouin, S. G., & Blériot, Y. (2017). Multivalency To Inhibit and Discriminate Hexosaminidases. Chemistry – A European Journal, 23(38), 9022–9025. https://doi.org/10.1002/chem.201701756

Date created: 
2017-05-26
Identifier: 
DOI: 10.1002/chem.201701756
Keywords: 
Exo-N-acetyl-b-glucosaminidases
Glycoclusters
Glycosidases
Iminosugars
Multivalency
Abstract: 

A set of multivalent polyhydroxylated acetamidoazepanes based on ethylene glycol, glucoside, or cyclodextrin scaffolds was prepared. The compounds were assessed against plant, mammalian, and therapeutically relevant hexosaminidases. Multimerization was shown to improve the inhibitory potency with synergy, and to fine tune the selectivity profile between related hexosaminidases.

Language: 
English
Document type: 
Article
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Rights remain with the authors.
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