Synthesis of conformationally constrained inhibitors for glycoside hydrolases

Author: 
Date created: 
2019-09-10
Identifier: 
etd20587
Keywords: 
Glycoside hydrolase
Gaucher disease
Fabry's disease
Transition state analogue
Inhibitor
Abstract: 

Glycoside hydrolase (GH) enzymes are clinically relevant biological targets for drug development. Disfunction of the two lysosomal GHs β-glucocerebrosidase and α-galactosidase can lead to Gaucher and Fabry’s disease, respectively. With knowledge of their mechanisms of action it is possible to create compounds that would effectively modulate their activity and potentially restore the activity of dysfunctional enzymes. Therefore, this work considers the approach to the synthesis of such compounds and determination of their mode of action. In the future, these compounds can be used for the development of drug candidates.

Document type: 
Thesis
Rights: 
This thesis may be printed or downloaded for non-commercial research and scholarly purposes. Copyright remains with the author.
File(s): 
Senior supervisor: 
Andrew Bennet
Department: 
Science: Department of Chemistry
Thesis type: 
(Thesis) M.Sc.
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