White Matter fMRI Activation Cannot Be Treated as a Nuisance Regressor: Overcoming a Historical Blind Spot

Peer reviewed: 
Yes, item is peer reviewed.
Scholarly level: 
Faculty/Staff
Final version published as: 

Grajauskas LA, Frizzell T, Song X and D’Arcy RCN (2019) White Matter fMRI Activation Cannot Be Treated as a Nuisance Regressor: Overcoming a Historical Blind Spot. Front. Neurosci. 13:1024. DOI: 10.3389/fnins.2019.01024.

Date created: 
2019-10-04
Keywords: 
White matter
BOLD
fMRI
Motion regression
fMRI analysis
Abstract: 

Despite past controversies, increasing evidence has led to acceptance that white matter activity is detectable using functional magnetic resonance imaging (fMRI). In spite of this, advanced analytic methods continue to be published that reinforce a historic bias against white matter activation by using it as a nuisance regressor. It is important that contemporary analyses overcome this blind spot in whole brain functional imaging, both to ensure that newly developed noise regression techniques are accurate, and to ensure that white matter, a vital and understudied part of the brain, is not ignored in functional neuroimaging studies.

Language: 
English
Document type: 
Article
File(s): 
Sponsor(s): 
Natural Sciences and Engineering Research Council of Canada (NSERC)
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