Host-guest Interaction at Molecular Interfaces: Binding of Cucurbit[7]uril on Ferrocenyl Self-assembled Monolayers on Gold

Peer reviewed: 
Yes, item is peer reviewed.
Scholarly level: 
Faculty/Staff
Final version published as: 

Qi, L.; Tian, H.; Shao, H.; Yu, H.-Z.  Host-guest Interaction at Molecular Interfaces: Binding of Cucurbit[7]uril on Ferrocenyl Self-assembled Monolayers on Gold. Journal of Physical Chemistry C, 2017, 121 (14), pp 7985–7992.

DOI: 10.1021/acs.jpcc.7b01135

Date created: 
2017-03-22
Identifier: 
DOI: 10.1021/acs.jpcc.7b01135
Abstract: 

Ferrocene (Fc) encapsulated cucurbit[7]uril (CB[7]) supramolecular host-guest complex  (Fc@CB[7]) as a synthetic recognition pair has been widely adapted for coupling biomolecules and nanomaterials due to its ultra-high binding affinity. In this paper, we have explored the binding of CB[7] on binary ferrocenylundecanethiolate/octanethiolate self-assembled monolayer on gold  (FcC11S-/C8S-Au), a model system to deepen our understanding of host-guest chemistry at molecular interfaces. It has been shown that upon incubation with CB[7] solution, the redox behavior FcC11S-/C8S-Au changes remarkably, i.e., a new pair of peaks appeared at more positive potential with narrowed widths. The ease of quantitation of surface bound-redox species (Fc+/Fc and  Fc+@CB[7]/ Fc@CB[7]) enabled us to determine the thermodynamic formation constant of  Fc@CB[7] at FcC11S-/C8S-Au (7.3±1.8 × 104 M-1). With time-dependent redox responses, we were able to, for the first time, deduce both the binding and dissociation rate constants, 2.8±0.3 × 103  M-1s-1 and 0.08±0.01 s-1, respectively. These results showed substantial differences both thermodynamically and kinetically for the formation of host-guest inclusion complex at molecular interfaces with respect to solution-diffused, homogenous environments.

Description: 

The full text of this paper will be available on April 1, 2018 in accordance with the embargo periods of the American Chemical Society and in keeping with the Open Access requirements of NSERC funded research. If you require a fulltext copy of this paper before April 2018 please contact summit@sfu.ca

Language: 
English
Document type: 
Article
Rights: 
Rights remain with the author.
Sponsor(s): 
Natural Sciences and Engineering Research Council of Canada (NSERC)
Natural Science Foundation of China
China Scholarship Council
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