Significant Role of the Cardiopostural Interaction in Blood Pressure Regulation During Standing

Peer reviewed: 
Yes, item is peer reviewed.
Scholarly level: 
Faculty/Staff
Final version published as: 

Xu D, Verma AK, Garg A, Bruner M, Fazel-Rezai R, Blaber AP, and Tavakolian K (2017). Significant role of the cardio-postural interaction in blood pressure regulation during standing.  Am J Physiol Heart Circ Physiol, 313(3): H568-577.         DOI: 10.1152/ajpheart.00836.2016

Identifier: 
DOI: 10.1152/ajpheart.00836.2016
Keywords: 
Cardio-postural control
Skeletal muscle pump
Orthostatic hypotension
Mild exercise
Abstract: 

Cardiovascular and postural control systems have been studied independently despite the increasing evidence showing the importance of cardio-postural interaction in blood pressure regulation. In this study, we aimed to assess the role of cardio-postural interaction in relation to cardiac baroreflex in blood pressure regulation under orthostatic stress before and after mild exercise. Physiological variables representing cardiovascular control (heart rate and systolic blood pressure), lower limb muscle activation (electromyography), and postural sway (center of pressure derived from force and moment data during sway) were measured from 17 healthy participants (25±2 years; 8 females) during a sit-to stand test before and after sub-maximal exercise. The cardio-postural control (characterized by baroreflex-mediated muscle-pump effect in response to blood pressure changes, i.e., muscle-pump baroreflex) was assessed using wavelet transform coherence and causality analyses in relation to the baroreflex control of heart rate. Significant cardio-postural blood pressure control was evident counting for almost half of the interaction time with blood pressure changes that observed in the cardiac baroreflex (36.6-72.5% pre-exercise and 34.7-53.9% post-exercise). Thus, cardio-postural input to blood pressure regulation should be considered when investigating orthostatic intolerance. A reduction of both cardiac and muscle-pump baroreflexes in blood pressure regulation was observed post-exercise and was likely due to the absence of excessive venous pooling and a less stressed system after mild exercise. With further studies using more effective protocols evoking venous pooling and muscle-pump activity, the cardio-postural interaction could improve our understanding of the autonomic control system and ultimately lead to a more accurate diagnosis of cardio-postural dysfunctions.

Description: 

This paper will be available in October 2018, once the 12 month embargo of the  American Journal of Physiology-Heart and Circulatory Physiology has expired.

Please contact summit@sfu.ca if you wish to obtain access to this paper prior to the expiration of the embargo period.

Language: 
English
Document type: 
Article
Rights: 
Rights remain with the authors.
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