Palladium-Catalyzed Allylation/Benzylation of H-Phosphinate Esters with Alcohols

Peer reviewed: 
Yes, item is peer reviewed.
Scholarly level: 
Faculty/Staff
Final version published as: 

Fers-Lidou A, Berger O, Montchamp JL. "Palladium-Catalyzed Allylation/Benzylation of H-Phosphinate Esters with Alcohols." Molecules. 2016 Sep 28;21(10).

Date created: 
2016-09
Keywords: 
Palladium
Cross-coupling
Alcohols
H-phosphinate esters
Allylation
Benzylation
Abstract: 

The Pd-catalyzed direct alkylation of H-phosphinic acids and hypophosphorous acid with allylic/benzylic alcohols has been described previously. Here, the extension of this methodology to H-phosphinate esters is presented. The new reaction appears general, although its scope is narrower than with the acids, and its mechanism is likely different. Various alcohols are examined in their reaction with phosphinylidene compounds R1R 2P(O)H.

Language: 
English
Document type: 
Article
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