Self-efficacy (SE) has been regarded the strongest cognitive determinant of cigarette use during pregnancy, but has yet to be assessed in pregnant women who use alternative modes of nicotine, including electronic nicotine delivery systems (ENDS). Knowing that nicotine is harmful to the fetus, more research on SE in pregnant ENDS users is warranted. Using data from the BC Healthy Connections Project, the purpose of this research was to identify differences in SE between pregnant: cigarette users; ENDS users; combination users (ENDS and cigarettes); and abstainers (no tobacco or nicotine). The relationship between SE and mode of nicotine was examined using multiple linear regression. Due to small sample sizes, ENDS and combination users were collapsed (ENDS/combination users). SE was significantly higher in ENDS/combination users compared to abstainers. No other significant group differences emerged. Results from this research can be used to tailor interventions aimed at reducing fetal exposure to nicotine.