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Molecular assessment of former cancer sites predicts second oral malignancy

Resource type
Thesis type
(Thesis) M.Sc.
Date created
2005
Authors/Contributors
Author: Li, Jinze
Abstract
Clinicopathological criteria currently used to identify lesions at risk for second oral malignancy (SOM) have severe limitations. This thesis investigated the value of loss of heterozygosity (LOH) as a risk-predictor for SOM. Eighty-nine patiknts with a history of oral cancer in longitudinal follow-up were used. Each patient had one sample (biopsy or brushing) analyzed for LOH using 19 markers on 7 chromosome arms. Within the follow-up period (mean 65 months), 28% developed SOMs. Brushing served as a valid DNA source for LOH analysis. An increased frequency of LOH observed at several loci was noted in samples from the SOM group compared with the non-SOM: 3p (P = 0.003), 4q (P = 0.045), 9p (P < 0.0001), 17p (P = 0.001), multiple LOH (P < 0.0001), and LOH at 3p &/or 9p (P < 0.0001). The latter pattern was associated with a 21.4-fold increase in SOM risk. In conclusion, LOH analysis could identify high-risk lesions for SOM using either biopsies or brushings.
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Scholarly level
Language
English
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