Engineering Science, School of

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Low Frequency Mechanical Actuation Accelerates Reperfusion In-Vitro

Peer reviewed: 
Yes, item is peer reviewed.
Date created: 
2013
Abstract: 

Background

Rapid restoration of vessel patency after acute myocardial infarction is key to reducing myocardial muscle death and increases survival rates. Standard therapies include thrombolysis and direct PTCA. Alternative or adjunctive emergency therapies that could be initiated by minimally trained personnel in the field are of potential clinical benefit. This paper evaluates a method of accelerating reperfusion through application of low frequency mechanical stimulus to the blood carrying vessels.

Materials and method

We consider a stenosed, heparinized flow system with aortic-like pressure variations subject to direct vessel vibration at the occlusion site or vessel deformation proximal and distal to the occlusion site, versus a reference system lacking any form of mechanical stimulus on the vessels.

Results

The experimental results show limited effectiveness of the direct mechanical vibration method and a drastic increase in the patency rate when vessel deformation is induced. For vessel deformation at occlusion site 95% of clots perfused within 11 minutes of application of mechanical stimulus, for vessel deformation 60 centimeters from the occlusion site 95% percent of clots perfused within 16 minutes of stimulus application, while only 2.3% of clots perfused within 20 minutes in the reference system.

Conclusion

The presented in-vitro results suggest that low frequency mechanical actuation applied during the pre-hospitalization phase in patients with acute myocardial infarction have potential of being a simple and efficient adjunct therapy.

Document type: 
Article
File(s): 

Statistical Validation Of Wavelet Transform Coherence Method To Assess The Transfer Of Calf Muscle Activation To Blood Pressure During Quiet Standing

Peer reviewed: 
Yes, item is peer reviewed.
Date created: 
2013
Abstract: 

Background

Continuous and discrete wavelet transforms have been established as valid tools to analyze non-stationary and transient signals over Fourier domain methods. Additionally, Fourier transform based coherence methods provide aggregate results but do not provide insights into the changes in coherent behavior over time, hence limiting their utility.

Methods

Statistical validation of the wavelet transform coherence (WTC) was conducted with simulated data sets. Time frequency maps of signal coherence between calf muscle electromyography (EMG) and blood pressure (BP) were obtained by WTC to provide further insight into their interdependent time-varying behavior via the skeletal muscle pump during quiet stance. Data were collected from healthy young males (n = 5, 19–28 years) during a quiet stance on a balance platform. Waveforms for EMG and BP were acquired and processed for further analysis.

Results

Low values of bias and standard deviation (< 0.1) were observed and the use of both simulated and real data demonstrated that the WTC method was able to identify time points of significant coherence (> Threshold) and objectively detect existence of interdependent activity between the calf muscle EMG and blood pressure.

Conclusions

The WTC method effectively identified the presence of linear coupling between the EMG and BP signals during quiet standing. Future studies with more human data are needed to establish the exact characteristics of the identified relationship.

Document type: 
Article
File(s): 

Are Compression Stockings an Effective Treatment for Orthostatic Presyncope?

Peer reviewed: 
Yes, item is peer reviewed.
Date created: 
2011
Abstract: 

Syncope, or fainting, affects approximately 6.2% of the population, and is associated with significant comorbidity. Many syncopal events occur secondary to excessive venous pooling and capillary filtration in the lower limbs when upright. As such, a common approach to the management of syncope is the use of compression stockings. However, research confirming their efficacy is lacking. We aimed to investigate the effect of graded calf compression stockings on orthostatic tolerance.

Document type: 
Article

Location-Aware Cross-Layer Design Using Overlay Watermarks

Peer reviewed: 
Yes, item is peer reviewed.
Date created: 
2007
Abstract: 

A new orthogonal frequency division multiplexing (OFDM) system embedded with overlay watermarks for location-aware cross-layer design is proposed in this paper. One major advantage of the proposed system is the multiple functionalities the overlay watermark provides, which includes a cross-layer signaling interface, a transceiver identification for position-aware routing, as well as its basic role as a training sequence for channel estimation. Wireless terminals are typically battery powered and have limited wireless communication bandwidth. Therefore, efficient collaborative signal processing algorithms that consume less energy for computation and less bandwidth for communication are needed. Transceiver aware of its location can also improve the routing efficiency by selective flooding or selective forwarding data only in the desired direction, since in most cases the location of a wireless host is unknown. In the proposed OFDM system, location information of a mobile for efficient routing can be easily derived when a unique watermark is associated with each individual transceiver. In addition, cross-layer signaling and other interlayer interactive information can be exchanged with a new data pipe created by modulating the overlay watermarks. We also study the channel estimation and watermark removal techniques at the physical layer for the proposed overlay OFDM. Our channel estimator iteratively estimates the channel impulse response and the combined signal vector from the overlay OFDM signal. Cross-layer design that leads to low-power consumption and more efficient routing is investigated.

Document type: 
Article

Development of a Novel Contactless Mechanocardiograph Device

Peer reviewed: 
Yes, item is peer reviewed.
Date created: 
2008
Abstract: 

A novel method of detecting mechanical movement of the heart, Mechanocardiography (MCG), with no connection to the subject's body is presented. This measurement is based on radar technology and it has been proven through this research work that the acquired signal is highly correlated to the phonocardiograph signal and acceleration-based ballistocardiograph signal (BCG) recorded directly from the sternum. The heart rate and respiration rate have been extracted from the acquired signal as two possible physiological monitoring applications of the radar-based MCG device.

Document type: 
Article

On Reliable Transmission of Data over Simple Wireless Channels

Peer reviewed: 
Yes, item is peer reviewed.
Date created: 
2009
Abstract: 

Standard protocols for reliable data transmission over unreliable channels are based on various Automatic Repeat reQuest (ARQ) schemes, whereby the sending node receives feedback from the receiver and retransmits the missing data. We discuss this issue in the context of one-way data transmission over simple wireless channels characteristic of many sensing and monitoring applications. Using a specific project as an example, we demonstrate how the constraints of a low-cost embedded wireless system get in the way of a workable solution precluding the use of popular schemes based on windows and periodic acknowledgments. We also propose an efficient solution to the problem and demonstrate its advantage over the traditional protocols.

Document type: 
Article

Robust Nash Dynamic Game Strategy for User Cooperation Energy Efficiency in Wireless Cellular Networks

Peer reviewed: 
Yes, item is peer reviewed.
Date created: 
2012
Abstract: 

Recently, there is an emerging trend of addressing “energy efficiency” aspect of wireless communications. It has been shown that cooperating users relay each other's information to improve data rates. The energy is limited in the wireless cellular network, but the mobile users refuse to relay. This paper presents an approach that encourages user cooperation in order to improve the energy efficiency. The game theory is an efficient method to solve such conflicts. We present a cellular framework in which two mobile users, who desire to communicate with a common base station, may cooperate via decode-and-forward relaying. In the case of imperfect information assumption, cooperative Nash dynamic game is used between the two users' cooperation to tackle the decision making problems: whether to cooperate and how to cooperate in wireless networks. The scheme based on “cooperative game theory” can achieve general pareto-optimal performance for cooperative games, and thus, maximize the entire system payoff while maintaining fairness.

Document type: 
Article

Discrete Artificial Bee Colony for Computationally Efficient Symbol Detection in Multidevice STBC MIMO Systems

Peer reviewed: 
Yes, item is peer reviewed.
Date created: 
2013
Abstract: 

A Discrete Artificial Bee Colony (DABC) is presented for joint symbol detection at the receiver in a multidevice Space-Time Block Code (STBC) Mutli-Input Multi-Output (MIMO) communication system. Exhaustive search (maximum likelihood detection) for finding an optimal detection has a computational complexity that increases exponentially with the number of mobile devices, transmit antennas per mobile device, and the number of bits per symbol. ABC is a new population-based, swarm-based Evolutionary Algorithms (EA) presented for multivariable numerical functions and has shown good performance compared to other mainstream EAs for problems in continuous domain. This algorithm simulates the intelligent foraging behavior of honeybee swarms. An enhanced discrete version of the ABC algorithm is presented and applied to the joint symbol detection problem to find a nearly optimal solution in real time. The results of multiple independent simulation runs indicate the effectiveness of DABC with other well-known algorithms previously proposed for joint symbol detection such as the near-optimal sphere decoding, minimum mean square error, zero forcing, and semidefinite relaxation, along with other EAs such as genetic algorithm, estimation of distributions algorithm, and the more novel biogeography-based optimization algorithm.

Document type: 
Article

The RSU Access Problem Based on Evolutionary Game Theory for VANET

Peer reviewed: 
No, item is not peer reviewed.
Date created: 
2013
Abstract: 

We identify some challenges in RSU access problem. There are two main problems in V2R      communication. (1) It is difficult to maintain the end-to-end connection between vehicles and RSU due to the high mobility of vehicles. (2) The limited RSU bandwidth resources lead to the vehicles’ disorderly competition behavior, which will give rise to multiple RSUs having overlap area environment where RSU access becomes crucial for increasing vehicles’ throughput. Focusing on the problems mentioned above, the RSU access question in the paper is formulated as a dynamic evolutionary game for studying the competition of vehicles in the single community and among multiple communities to share the limited bandwidth in the available RSUs, and the evolutionary equilibrium evolutionary stable strategy (ESS) is considered to be the solution to this game. Simulation results based on a realistic vehicular traffic model demonstrate the evolution process of the game and how the ESS can affect the network performance.

Document type: 
Article