Physics, Department of

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A Novel Approach to Modelling Water Transport and Drug Diffusion Through the Stratum Corneum

Peer reviewed: 
Yes, item is peer reviewed.
Date created: 
2010
Abstract: 

Background: The potential of using skin as an alternative path for systemicallyadministering active drugs has attracted considerable interest, since the creation ofnovel drugs capable of diffusing through the skin would provide a great steptowards easily applicable -and more humane- therapeutic solutions. However, fordrugs to be able to diffuse, they necessarily have to cross a permeability barrier: thestratum corneum (SC), the uppermost set of skin layers. The precise mechanism bywhich drugs penetrate the skin is generally thought to be diffusion of moleculesthrough this set of layers following a “tortuous pathway” around corneocytes, i.e.impermeable dead cells.Results: In this work, we simulate water transport and drug diffusion using a threedimensionalporous media model. Our numerical simulations show that diffusiontakes place through the SC regardless of the direction and magnitude of the fluidpressure gradient, while the magnitude of the concentrations calculated areconsistent with experimental studies.Conclusions: Our results support the possibility for designing arbitrary drugs capableof diffusing through the skin, the time-delivery of which is solely restricted by theirdiffusion and solubility properties.

Document type: 
Article

Perpendicular media with Cr-doped Fe-alloy-containing soft underlayer (SUL) for improved corrosion performance. US Patent #7,566,508

Peer reviewed: 
No, item is not peer reviewed.
Date created: 
2009-07-28
Abstract: 

A perpendicular magnetic recording medium having a substrate, a Cr-doped Fe-alloy-containing underlayer containing about 8 to 18 at % Cr and a perpendicular recording magnetic layer, and a process for improving corrosion resistance of the recording medium and for manufacturing the recording medium are disclosed.

Document type: 
Other
File(s): 

Anti-ferromagnetically coupled soft underlayer. US Patent #7,666,529

Peer reviewed: 
No, item is not peer reviewed.
Date created: 
2010-02-23
Abstract: 

A magnetic recording medium having a first magnetic layer, a spacer layer, and a second magnetic layer, in this order, wherein the spacer layer includes a non-magnetic layer and a thickness of the spacer layer is selected to establish anti-ferromagnetic coupling between the first magnetic layer and the second magnetic layer, and a thickness of both the first and second magnetic layers are less than a critical thickness for formation of stripe domains in the magnetic layers is disclosed.

Document type: 
Other
File(s): 

Magnetic storage media with Ag, Au-containing magnetic layers. US Patent #7,736,766

Peer reviewed: 
No, item is not peer reviewed.
Date created: 
2010-06-15
Abstract: 

A magnetic recording medium having a Au, Ag-containing magnetic layer having Co, Cr, Ag and Au; the magnetic recording layer having Co-containing magnetic grains surrounded by substantially nonmagnetic Cr-containing grain boundaries; wherein said Ag and said Au are substantially immiscible in the Co-containing magnetic grains is disclosed.

Document type: 
Other
File(s): 

Anti-ferromagnetically coupled perpendicular magnetic recording media with oxide. US Patent #7,842,409

Author: 
Peer reviewed: 
No, item is not peer reviewed.
Date created: 
2010-11-30
Abstract: 

The present invention relates to perpendicular magnetic recording media with improved signal-to-medium noise ratio (“SMNR”) and thermal stability, which media include a pair of vertically spaced-apart perpendicular ferromagnetic layers which are anti-ferromagnetically coupled (“AFC”) across a non-magnetic spacer layer. The invention is of particular utility in the fabrication of data/information storage and retrieval media, e.g., hard disks, having ultra-high areal recording/storage densities.

Document type: 
Other
File(s): 

Low coupling oxide media (LCOM). US Patent #7,867,637

Peer reviewed: 
No, item is not peer reviewed.
Date created: 
2011-01-11
Abstract: 

A low-coupling perpendicular magnetic recording media comprising a magnetic storage layer and at least one low saturation magnetization layer. The magnetic storage layer has a saturation magnetization between about 400-900 emu/cm3 and the at least one low saturation magnetization layer has a saturation magnetization below that of the magnetic storage layer.

Document type: 
Other
File(s): 

Single-pass recording of multilevel patterned media. US Patent #7,974,031

Peer reviewed: 
No, item is not peer reviewed.
Date created: 
2011-07-05
Abstract: 

A method of performing data/information recording and retrieval utilizing a multilevel patterned magnetic medium, comprises providing a magnetic recording system including a read/write head and a multilevel patterned magnetic recording medium including a plurality of spaced apart data/information storage elements each comprising a stacked plurality n of magnetic recording cells with different magnetic properties and magnetically decoupled from overlying and/or underlying cells; providing relative movement between the write head and magnetic recording medium; and writing to the medium by supplying the write head with a modulated write current comprising a plurality n of pulses of different magnitudes while the head passes over each element, thereby applying n different magnetic field strengths to each element, such that the writing occurs in a single pass of the write head over each element.

Document type: 
Other
File(s): 

Perpendicular media with Cr-doped Fe-alloy-containing soft underlayer (SUL). US Patent #7,998,606

Peer reviewed: 
No, item is not peer reviewed.
Date created: 
2011-08-16
Abstract: 

A perpendicular magnetic recording medium having a substrate, a Cr-doped Fe-alloy-containing underlayer containing about 8 to 18 at % Cr and a perpendicular recording magnetic layer, and a process for improving corrosion resistance of the recording medium and for manufacturing the recording medium are disclosed.

Document type: 
Other
File(s): 

Magnetic storage media with Ag, Au-containing magnetic layers. US Patent #8,101,292

Peer reviewed: 
No, item is not peer reviewed.
Date created: 
2012-01-24
Abstract: 

A magnetic recording medium having a Au, Ag-containing magnetic layer having Co, Cr, Ag and Au; the magnetic recording layer having Co-containing magnetic grains surrounded by substantially nonmagnetic Cr-containing grain boundaries; wherein said Ag and said Au are substantially immiscible in the Co-containing magnetic grains.

Document type: 
Other
File(s):