Chemistry - Theses, Dissertations, and other Required Graduate Degree Essays

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Niobium trichloride-mediated coupling reactions of imines with electrophiles

Peer reviewed: 
No, item is not peer reviewed.
Date created: 
2003
Document type: 
Thesis
File(s): 
Supervisor(s): 
P.D. Wilson
Department: 
Science: Department of Chemistry
Thesis type: 
(Thesis) M.Sc.

Synthesis and enzymatic evaluation of alpha-galactosidase inhibitors

Author: 
Peer reviewed: 
No, item is not peer reviewed.
Date created: 
2007
Abstract: 

The compounds containing a structural motif of a cyclopropyl ring fused onto a carba-galactopyranose skeleton were synthesized and tested as potential reversible and irreversible £\-galactosidase inhibitors. (1R,2S,3S,4S,5S,6S)-5-amino-1-(hydroxymethyl)bicyclo[4.1.0]heptan-2,3,4-triol and (1S,2S,3S,4S,5S,6R)-5-amino-1-(hydroxymethyl)bicyclo[4.1.0]heptan-2,3,4-triol were synthesized from methyl £\-D-galactopyranoside. A kinetic study showed the later compound is not a inhibitor. However the former is a potent reversible inhibitor of coffee bean £\-galactosidase with a Ki value of 541 nM. (1R,2S,3S,4R,5S,6S)-5-(3,5-difluorophenoxy)-1-(hydroxymethyl) bicyclo[4.1.0]heptan-2,3,4-triol and (1S,2S,3S,4R,5S,6R)-5-(3,5-difluorophenoxy)-1-(hydroxymethyl)bicyclo[4.1.0]heptan-2,3,4-triol were synthesized as irreversible inhibitors of £\-galactosidases. Analysis of inhibitory kinetic data illustrated that the former compound is an irreversible inhibitor for coffee bean £\-gal! actosidase with inactivation rate constant (kinact) of 5.6 „e 10-4 s-1 and has a dissociation constant (Ki) of 4.1 mM. Furthermore, using the competitive inhibitor, (1R,2S,3S,4S,5S,6S)-5-amino-1-(hydroxymethyl)bicyclo[4.1.0]heptan-2,3,4-triol, to protect the enzyme from inactivation confirmed that inactivation of the £\-galactosidase enzyme by (1R,2S,3S,4R,5S,6S)-5-(3,5-difluorophenoxy)-1-(hydroxymethyl)bicyclo[4.1.0]heptan-2,3,4-triol occurred in the active site.

Document type: 
Thesis
File(s): 
Supervisor(s): 
Andrew J. Bennet
Department: 
Science: Department of Chemistry
Thesis type: 
(Thesis) M.Sc.

Wall-less sample preparation strategies for matrix-assisted laser desorption/ionization mass spectrometry analysis of biomolecules

Author: 
Peer reviewed: 
No, item is not peer reviewed.
Date created: 
2004
Document type: 
Thesis
File(s): 
Supervisor(s): 
G.R. Agnes
Department: 
Science: Department of Chemistry
Thesis type: 
(Dissertation) Ph.D.

Reactions of methylflurosilanes with singlet methylene and with nitric oxide (4(pi))

Peer reviewed: 
No, item is not peer reviewed.
Date created: 
1984
Document type: 
Thesis
File(s): 
Supervisor(s): 
T.N. Bell
A.G. Sherwood
Department: 
Science: Department of Chemistry
Thesis type: 
(Dissertation) Ph.D.

Synthesis and phase diagrams of the lead magnesium niobate-lead titanate-lead oxide system

Author: 
Peer reviewed: 
No, item is not peer reviewed.
Date created: 
2003
Document type: 
Thesis
File(s): 
Supervisor(s): 
Z-G. Ye
Department: 
Science: Department of Chemistry
Thesis type: 
(Thesis) M.Sc.

Chemistry of tetradecacarbonyltetraosmium

Author: 
Peer reviewed: 
No, item is not peer reviewed.
Date created: 
2004
Document type: 
Thesis
File(s): 
Supervisor(s): 
Roland Pomeroy
Department: 
Science: Department of Chemistry
Thesis type: 
(Dissertation) Ph.D.

Studies on the hydrolysis mechanisms of sialosides and synthesis and evaluation of a bicyclo[4.1.0]heptyl analogue of glucose-1-phosphate

Author: 
Peer reviewed: 
No, item is not peer reviewed.
Date created: 
2004
Document type: 
Thesis
File(s): 
Supervisor(s): 
A.J. Bennet
Department: 
Science: Department of Chemistry
Thesis type: 
(Dissertation) Ph.D.

Synthesis of Centro-substituted triquinacene derivatives

Peer reviewed: 
No, item is not peer reviewed.
Date created: 
2004
Document type: 
Thesis
File(s): 
Supervisor(s): 
Peter D. Wilson
Department: 
Science: Department of Chemistry
Thesis type: 
(Dissertation) Ph.D.

Investigation of mercury cyanide as a building block in the formation of supramolecular coordination compounds

Author: 
Peer reviewed: 
No, item is not peer reviewed.
Date created: 
2004
Document type: 
Thesis
File(s): 
Supervisor(s): 
D.B Leznoff
Department: 
Science: Department of Chemistry
Thesis type: 
Thesis (M.Sc.)