Chemistry - Theses, Dissertations, and other Required Graduate Degree Essays

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The effect of molecular shape and symmetry on discotic mesogens

Author: 
Date created: 
2010-04-01
Abstract: 

In the field of material science, structure/property relationships can allow a more efficient design of materials exhibiting the desired properties. Self-assembled super-structures possess several advantages that can be exploited. The formation of complex architecture is dictated by the properties of the small sub-units. The formation of liquid crystalline phases requires molecular anisotropy, which is often achieved by using flat rigid rod or disc-shaped cores decorated with aliphatic chains. Other structural morphologies have also proven to allow the formation of these ordered fluid phases: plate, bent-core, bowl etc. Our research group is interested in disc-shaped molecules that have the ability to form liquid crystalline phases constituted of columns distributed in a two-dimensional lattice. The discs within a column are stacked on top of each other that could be used to conduct either energy or charges. The research projects presented in this thesis were concerned in establishing the effect of molecular symmetry and shape on the mesogenic properties of compounds based on a dibenz[a,c]phenazine core decorated with alkoxy chains (four and six). Series of structural isomers have been synthesized and their mesogenic behaviour analyzed. Reducing the molecular symmetry of mesogens lowers the melting temperature and, to a smaller extent, the clearing temperature leading to broader liquid temperature ranges of mesogenic behaviour. To study the effect of molecular shape, compounds with chains of different length and different motifs were prepared. This type of substitution leads to different mesogenic behaviour. Comparisons between structural isomers showed that this new substitution pattern lowered the clearing temperatures for these mesophases. The molecular shape of these compounds does have an effect on the mesophase and the results could allow more efficient engineering of systems used in various devices.

Document type: 
Thesis
File(s): 
Senior supervisor: 
Vance E. Williams
Department: 
Science: Department of Chemistry
Thesis type: 
(Thesis) Ph.D.

Niobium trichloride-mediated coupling reactions of imines with electrophiles

Peer reviewed: 
No, item is not peer reviewed.
Date created: 
2003
Document type: 
Thesis
File(s): 
Senior supervisor: 
P.D. Wilson
Department: 
Science: Department of Chemistry
Thesis type: 
(Thesis) M.Sc.

Synthesis and enzymatic evaluation of alpha-galactosidase inhibitors

Author: 
Peer reviewed: 
No, item is not peer reviewed.
Date created: 
2007
Abstract: 

The compounds containing a structural motif of a cyclopropyl ring fused onto a carba-galactopyranose skeleton were synthesized and tested as potential reversible and irreversible £\-galactosidase inhibitors. (1R,2S,3S,4S,5S,6S)-5-amino-1-(hydroxymethyl)bicyclo[4.1.0]heptan-2,3,4-triol and (1S,2S,3S,4S,5S,6R)-5-amino-1-(hydroxymethyl)bicyclo[4.1.0]heptan-2,3,4-triol were synthesized from methyl £\-D-galactopyranoside. A kinetic study showed the later compound is not a inhibitor. However the former is a potent reversible inhibitor of coffee bean £\-galactosidase with a Ki value of 541 nM. (1R,2S,3S,4R,5S,6S)-5-(3,5-difluorophenoxy)-1-(hydroxymethyl) bicyclo[4.1.0]heptan-2,3,4-triol and (1S,2S,3S,4R,5S,6R)-5-(3,5-difluorophenoxy)-1-(hydroxymethyl)bicyclo[4.1.0]heptan-2,3,4-triol were synthesized as irreversible inhibitors of £\-galactosidases. Analysis of inhibitory kinetic data illustrated that the former compound is an irreversible inhibitor for coffee bean £\-gal! actosidase with inactivation rate constant (kinact) of 5.6 „e 10-4 s-1 and has a dissociation constant (Ki) of 4.1 mM. Furthermore, using the competitive inhibitor, (1R,2S,3S,4S,5S,6S)-5-amino-1-(hydroxymethyl)bicyclo[4.1.0]heptan-2,3,4-triol, to protect the enzyme from inactivation confirmed that inactivation of the £\-galactosidase enzyme by (1R,2S,3S,4R,5S,6S)-5-(3,5-difluorophenoxy)-1-(hydroxymethyl)bicyclo[4.1.0]heptan-2,3,4-triol occurred in the active site.

Document type: 
Thesis
File(s): 
Senior supervisor: 
Andrew J. Bennet
Department: 
Science: Department of Chemistry
Thesis type: 
(Thesis) M.Sc.

Wall-less sample preparation strategies for matrix-assisted laser desorption/ionization mass spectrometry analysis of biomolecules

Author: 
Peer reviewed: 
No, item is not peer reviewed.
Date created: 
2004
Document type: 
Thesis
File(s): 
Senior supervisor: 
G.R. Agnes
Department: 
Science: Department of Chemistry
Thesis type: 
(Dissertation) Ph.D.

Reactions of methylflurosilanes with singlet methylene and with nitric oxide (4(pi))

Peer reviewed: 
No, item is not peer reviewed.
Date created: 
1984
Document type: 
Thesis
File(s): 
Senior supervisor: 
T.N. Bell
A.G. Sherwood
Department: 
Science: Department of Chemistry
Thesis type: 
(Dissertation) Ph.D.

Synthesis and phase diagrams of the lead magnesium niobate-lead titanate-lead oxide system

Author: 
Peer reviewed: 
No, item is not peer reviewed.
Date created: 
2003
Document type: 
Thesis
File(s): 
Senior supervisor: 
Z-G. Ye
Department: 
Science: Department of Chemistry
Thesis type: 
(Thesis) M.Sc.

Chemistry of tetradecacarbonyltetraosmium

Author: 
Peer reviewed: 
No, item is not peer reviewed.
Date created: 
2004
Document type: 
Thesis
File(s): 
Senior supervisor: 
Roland Pomeroy
Department: 
Science: Department of Chemistry
Thesis type: 
(Dissertation) Ph.D.

Studies on the hydrolysis mechanisms of sialosides and synthesis and evaluation of a bicyclo[4.1.0]heptyl analogue of glucose-1-phosphate

Author: 
Peer reviewed: 
No, item is not peer reviewed.
Date created: 
2004
Document type: 
Thesis
File(s): 
Senior supervisor: 
A.J. Bennet
Department: 
Science: Department of Chemistry
Thesis type: 
(Dissertation) Ph.D.

Synthesis of Centro-substituted triquinacene derivatives

Peer reviewed: 
No, item is not peer reviewed.
Date created: 
2004
Document type: 
Thesis
File(s): 
Senior supervisor: 
Peter D. Wilson
Department: 
Science: Department of Chemistry
Thesis type: 
(Dissertation) Ph.D.